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A few that I thought of recently:

Out of the pan and into the kettle black
On the bleeding edge of your seat
Raining teeth and nails

Pig in a jacket

I wanted to post a few I can't up with recently:
Don't judge a book until you've walked a mile in its dust jacket.
Squealing like a stuck pig in a poke.

Cutting through the hoops

Ciamh came up with a good one (accidentally I might add):
There's a lot of red tape to jump through

It's not over until the fat lady comes home to roost.

A snowball's chance of freezing hell over

Smooth Dreams

Last night I was really tired and said to my wife, "I'm going to sleep like a baby's bottom."

old one

I don't know if I've posted this one or not, but here it is:
Wicked Red-headed stepmother

Cracked

Just talking to my friend Chloe about applying to grad schools, and I used the expression: "Putting all your eggs in someone else's basket."

Katie just sent me a good one from Mad Men season 3:

There's no use crying over fish in the sea.

Much delayed update!

Well here's a few more. Hey - it's better than nothing!
From Chloë:

I overheard someone say "It all boils down to the wire"
Grasping at the last straw

From Gio:

Shoot fish in a barrel fist, ask questions later.

A few cracking mixed metaphors from me
You can't walk on eggshells without cracking a few eggs.
You can't put all your eggs in one basket without cracking a few eggs.
Don't count your chickens before you've cracked a few eggs.

And Louis pointed me towards a scene from the movie Boondock Saints, which contains the following:

People in glass houses sink ships.
Don't cross the road if you can't get out of the kitchen.

Slosh around when you walk

Recently when talking to a friend about how hilarious the phrase "full of piss and vinegar" is, I came up with this one:
It's raining piss and vinegar.

While in Prague, I heard this one, from my little sister:
Don't get your nipples in a twist.

Also I came up with this one:
If she tells you to jump off a bridge, you say, "how high?"